Our findings highlight that the venues in which MSM are recruited have meaningful consequences in terms of the “types” of individuals who are reached. Men from bars and clubs were significantly younger, and were more likely to report use of hallucinogens and crack or cocaine. In contrast, men from reported the lowest levels of attachment to the gay and bisexual community and were the least likely to self-identify as gay. Men recruited from sex parties were significantly older, reported more symptoms of sexual compulsivity, more likely to be HIV-positive, more likely to report a history of STIs, and more likely to self-identify as a barebacker, than men recruited from the other two venues. This study compared three sexually active cohorts of MSM recruited via (recruited via modified time-space sampling), gay bars and clubs (recruited via time-space sampling), and private sex parties (identified via passive recruitment and listserves), finding mixed results with regard to differences in demographic characteristics, STI history, and psychosocial measures. With limited exceptions, few studies have systematically reported on psychosocial and demographic characteristic differences in samples of men who have sex with men (MSM) based on where they were recruited.